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Final Paper Topic Idea

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For my topic, I want to discuss antisocial personality disorder. There was one study that proposed an animal model for this disorder is 2003.

Toward an Animal Model for Antisocial Behavior: Parallels Between Mice and Humans (2003)
https://link.springer.com/article/10.1023/A:1025730901955

However, this model focused primarily on attack latencies. There is much more to this personality disorder than aggression. I want to use the knowledge we have on this disorder from people and other animal studies on antisocial behavior to propose a better way to use animals to model this disorder. There was a similar paper written about an animal model proposal for borderline personality disorder, and I want to do something similar to it but with antisocial personality disorder.

Toward an animal model of borderline personality disorder (2019)
https://link.springer.com/article/10.1007%2Fs00213-019-05289-x

We have such a lack of understanding of the neurobiological mechanisms that underlie personality disorders and I think a lot of that comes from the fact that we don't have reliable animal models. We need to look beyond Genome-Wide Association Studies.

 Low empathy-like behavior in male mice associates with impaired sociability, emotional memory, physiological stress reactivity and variations in neurobiological regulation (2017)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714342/

Intersections and Divergences Between Empathizing and Mentalizing: Development, Recent Advancements by Neuroimaging and the Future of Animal Modeling (2019)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754072/

Neural bases of antisocial behavior: a voxel-based meta-analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127028/
(talks about neuroimaging, not animal models)

Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behavior (2012)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405678/

Association of COL25A1 with comorbid antisocial personality disorder and substance dependence (2012)
https://www.ncbi.nlm.nih.gov/pubmed/22297151
(human based study)

Candidate Genes for Aggression and Antisocial Behavior: A Meta-analysis of Association Studies of the 5HTTLPR and MAOA-uVNTR
https://link.springer.com/article/10.1007%2Fs10519-014-9661-y

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