Skip to main content

Final Paper Topic Idea

By
For my topic, I want to discuss antisocial personality disorder. There was one study that proposed an animal model for this disorder is 2003.

Toward an Animal Model for Antisocial Behavior: Parallels Between Mice and Humans (2003)
https://link.springer.com/article/10.1023/A:1025730901955

However, this model focused primarily on attack latencies. There is much more to this personality disorder than aggression. I want to use the knowledge we have on this disorder from people and other animal studies on antisocial behavior to propose a better way to use animals to model this disorder. There was a similar paper written about an animal model proposal for borderline personality disorder, and I want to do something similar to it but with antisocial personality disorder.

Toward an animal model of borderline personality disorder (2019)
https://link.springer.com/article/10.1007%2Fs00213-019-05289-x

We have such a lack of understanding of the neurobiological mechanisms that underlie personality disorders and I think a lot of that comes from the fact that we don't have reliable animal models. We need to look beyond Genome-Wide Association Studies.

 Low empathy-like behavior in male mice associates with impaired sociability, emotional memory, physiological stress reactivity and variations in neurobiological regulation (2017)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714342/

Intersections and Divergences Between Empathizing and Mentalizing: Development, Recent Advancements by Neuroimaging and the Future of Animal Modeling (2019)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754072/

Neural bases of antisocial behavior: a voxel-based meta-analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127028/
(talks about neuroimaging, not animal models)

Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behavior (2012)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405678/

Association of COL25A1 with comorbid antisocial personality disorder and substance dependence (2012)
https://www.ncbi.nlm.nih.gov/pubmed/22297151
(human based study)

Candidate Genes for Aggression and Antisocial Behavior: A Meta-analysis of Association Studies of the 5HTTLPR and MAOA-uVNTR
https://link.springer.com/article/10.1007%2Fs10519-014-9661-y

Comments

Post a Comment

Popular posts from this blog

Week 2- Dopamine Modulation of Depressive-like Behaviors

By
The Chaudhury et al paper explored the neural circuit mechanisms involved in the dopamine modulation of certain symptoms of depression. In this study, the researchers looked at social interaction and sucrose preference as part of their social-defeat paradigm, which has been shown in the past to be indicative of depressive-like behaviors. Although I initially did not completely see the connection between the social-defeat stress model of depression and the tonic vs phasic firing of dopamine neurons, it seemed that susceptibility and resilience to stress played a role in the functional/behavioral effects of dopamine firing. It was interesting to see how chronic mild stress with phasic firing of VTA dopamine neurons converted even resilient mice into susceptible mice.  The Tye et al paper similarly looked at the dopamine modulation of depressive-like behaviors, focusing on motivation with the forced swim tests and open field tests, followed by measurement of anhedonia by quantifyi...
Post a Comment
Read more

Sial & Allsop

By
Sial et al. derived a novel approach for studying what they deem vicarious defeat stress (VSDS) as a model for MDD, PTSD, and other mood-related disorders as an alternative to the classical CSDS paradigm. Using adult male mice, they demonstrate that their model induces a robust and measurable social avoidant phenotype as well as other stress and anxiety related behavioral outputs. Their subsequent rescue study with chronic fluoxetine treatment shows reversal of the behavioral phenotypes and emphasizes the predictive validity of the model. Allsop et al. found that BLA-projecting ACC neurons preferentially encode socially derived aversive cue information by encoding the demonstrator’s distress response during observational learning, hence enabling acquisition of negative valence of cue by BLA neurons and behavioral output. In order to test their hypothesis, Allsop et al. used an observational fear conditional paradigm to create association between a conditioned stimulu...
Post a Comment
Read more

Buffington and Reber

By
Buffington et al. explore a mechanism by which maternal obesity can induce neuronal and subsequent behavioral disorders. Using a model of high-fat diet (MHFD)-induced obesity, the authors showcase the strong connection between the brain and the gut, and its impact on behavior. The findings are provocative; by exposing these offspring to the microbiome of control offspring, there was evidence of a rescued observed behavioral phenotype. Furthermore, a phylogenetic profiling of the gut microbiome revealed a decrease in L. reuteri within MHFD offspring, and introduction of live L. reuteri into the drinking water shows successful rescue of the behavioral issues in the MHFD offspring. L. reuteri-induced expression of oxytocin within the paraventricular nuclei of the hypothalamus provides a potential mechanistic explanation for the behavioral changes. I thought this paper provided robust support for the hypothesized interaction between the gut biome and the developing CNS, with tremendous po...
Post a Comment
Read more